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Upstream Bio, Inc.

UPB · NASDAQ

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Reported smart-money activity for this stock is still below.

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UPBUpstream Bio, Inc.

Overview

No source-backed view yet. This page is available for price, fundamentals, and future receipts as coverage warms.

Key stats

Aug 20

52-wk high: $33.68
52-wk low: $5.85
Prev close: $21.73
Mkt cap: $411.6M
P/S: 130.3x
P/B: 1.4x

Smart money

8 funds hold a position.

Real smart money

Funds holding this stock

8 holders

Combined position$120.4M

MI
Millennium
Israel Englander · Q2 2026 13F
$7.9M
position
DS
D.E. Shaw
Q2 2026 13F

Earnings

Reported Aug 5, 2026

Earnings came in 6.4% above what analysts expected.

Documents

Quarterly report10-Q Annual report10-K

Financials

Fundamentals

Is the business strong?

This company is running thin margins.

Net margin: 0.0%
Market cap: $412M

Valuation

P/S130.34
P/B1.38

Quality

Operating margin-5481.0%
ROE

Technicals

Technicals

Price structure

No data yet

Technicals sync when verified market data is available. No sample data is shown.

Company

Symbol: UPB
Exchange: NASDAQ
Sector: HEALTHCARE
Industry: BIOTECHNOLOGY
Market cap: $411.60M

Analysts

What do analysts expect?

Analyst target and ratings are on paid plans

See the 12-month consensus target and the buy/hold/sell rating split.

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Disclaimer

© 2026 AlphaYou. All rights reserved.Not financial advice. Do your own research. Informational data only; past performance does not predict future results.

Profit margin

+0.0%

Op margin

-5481.0%

ROE

-46.1%

$7.2M

position

QR

Qube Research

Q2 2026 13F

$6.8M

position

5 more holders

Lite opens all of them for $16.50/month, paid yearly.

Unlock all 5 holders

Coverage gaps for UPB

No recent insider trade
No recent Congress trade
No recent market-voice mention

Earnings per share

-$0.73+6.4%

-$0.78 expected

Next report

What the street expects next

-46.1%

ROA-30.3%

Growth