John Paolini sold $8.9M of KNSA stock

By AlphaYouPublished Nov 4, 2026Form 4

Stocks in this disclosure

KNSAKiniksa Pharmaceuticals International, plc

Reported activity

Paolini John F.

Reporting filer

John Paolini reported selling 96,000 shares of Kiniksa Pharmaceuticals International, plc for about $8.9M ($93.09 a share on average). Form 4 filed Nov 3, 2026 lists 18 entries.

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Disclosed: Nov 3, 2026

Reported details

18 entries

All validated entries in this disclosure
Security	Owner	Date	Code	Action	Quantity	Price	Following holdings	Reporting delay	Filed terms and references
Class A Ordinary Share	Paolini John F.	2026-10-30	M	Exercise or conversion	38545	30.93	108,467	4 days	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 38545 transaction Price Per Share: 30.93 transaction Acquired Disposed Code: A shares Owned Following Transaction: 108467 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-10-30	M	Exercise or conversion	39042	17.92	147,509	4 days	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 39042 transaction Price Per Share: 17.92 transaction Acquired Disposed Code: A shares Owned Following Transaction: 147509 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-10-30	S	Sale	41789	92.02	105,720	4 days	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 41789 transaction Price Per Share: 92.02 id: F2 transaction Acquired Disposed Code: D shares Owned Following Transaction: 105720 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-10-30	S	Sale	16056	92.85	89,664	4 days	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 16056 transaction Price Per Share: 92.85 id: F3 transaction Acquired Disposed Code: D shares Owned Following Transaction: 89664 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-10-30	S	Sale	6841	93.91	82,823	4 days	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 6841 transaction Price Per Share: 93.91 id: F4 transaction Acquired Disposed Code: D shares Owned Following Transaction: 82823 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-10-30	S	Sale	4821	94.86	78,002	4 days	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 4821 transaction Price Per Share: 94.86 id: F5 transaction Acquired Disposed Code: D shares Owned Following Transaction: 78002 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-10-30	S	Sale	4000	95.97	74,002	4 days	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 4000 transaction Price Per Share: 95.97 id: F6 transaction Acquired Disposed Code: D shares Owned Following Transaction: 74002 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-10-30	S	Sale	1925	97.06	72,077	4 days	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 1925 transaction Price Per Share: 97.06 id: F7 transaction Acquired Disposed Code: D shares Owned Following Transaction: 72077 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-10-30	S	Sale	2155	97.77	69,922	4 days	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 2155 transaction Price Per Share: 97.77 id: F8 transaction Acquired Disposed Code: D shares Owned Following Transaction: 69922 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-11-02	M	Exercise or conversion	6455	30.93	76,377	1 day	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-11-02 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 6455 transaction Price Per Share: 30.93 transaction Acquired Disposed Code: A shares Owned Following Transaction: 76377 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-11-02	M	Exercise or conversion	11958	17.92	88,335	1 day	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-11-02 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 11958 transaction Price Per Share: 17.92 transaction Acquired Disposed Code: A shares Owned Following Transaction: 88335 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-11-02	S	Sale	899	92.37	87,436	1 day	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-11-02 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 899 transaction Price Per Share: 92.37 id: F9 transaction Acquired Disposed Code: D shares Owned Following Transaction: 87436 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-11-02	S	Sale	16810	93.42	70,626	1 day	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-11-02 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 16810 transaction Price Per Share: 93.42 id: F10 transaction Acquired Disposed Code: D shares Owned Following Transaction: 70626 direct Or Indirect Ownership: D nature Of Ownership:
Class A Ordinary Share	Paolini John F.	2026-11-02	S	Sale	704	94.09	69,922	1 day	Filed terms security Title: Class A Ordinary Share transaction Date: 2026-11-02 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 704 transaction Price Per Share: 94.09 id: F11 transaction Acquired Disposed Code: D shares Owned Following Transaction: 69922 direct Or Indirect Ownership: D nature Of Ownership:
Share Option (derivative)	Paolini John F.	2026-10-30	M	Exercise or conversion	38545	0	6,455	4 days	Filed terms security Title: Share Option conversion Or Exercise Price: 30.93 transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 38545 transaction Price Per Share: 0 transaction Acquired Disposed Code: D id: F12 expiration Date: 2028-09-19 underlying Security Title: Class A Ordinary Share underlying Security Shares: 38545 shares Owned Following Transaction: 6455 direct Or Indirect Ownership: D nature Of Ownership:
Share Option (derivative)	Paolini John F.	2026-10-30	M	Exercise or conversion	39042	0	11,958	4 days	Filed terms security Title: Share Option conversion Or Exercise Price: 17.92 transaction Date: 2026-10-30 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 39042 transaction Price Per Share: 0 transaction Acquired Disposed Code: D id: F12 expiration Date: 2029-03-03 underlying Security Title: Class A Ordinary Share underlying Security Shares: 39042 shares Owned Following Transaction: 11958 direct Or Indirect Ownership: D nature Of Ownership:
Share Option (derivative)	Paolini John F.	2026-11-02	M	Exercise or conversion	6455	0	0	1 day	Filed terms security Title: Share Option conversion Or Exercise Price: 30.93 transaction Date: 2026-11-02 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 6455 transaction Price Per Share: 0 transaction Acquired Disposed Code: D id: F12 expiration Date: 2028-09-19 underlying Security Title: Class A Ordinary Share underlying Security Shares: 6455 shares Owned Following Transaction: 0 direct Or Indirect Ownership: D nature Of Ownership:
Share Option (derivative)	Paolini John F.	2026-11-02	M	Exercise or conversion	11958	0	0	1 day	Filed terms security Title: Share Option conversion Or Exercise Price: 17.92 transaction Date: 2026-11-02 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 11958 transaction Price Per Share: 0 transaction Acquired Disposed Code: D id: F12 expiration Date: 2029-03-03 underlying Security Title: Class A Ordinary Share underlying Security Shares: 11958 shares Owned Following Transaction: 0 direct Or Indirect Ownership: D nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-10-30
Code: M
Action: Exercise or conversion
Quantity: 38545
Price: 30.93
Following holdings: 108,467
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 38545
transaction Price Per Share: 30.93
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 108467
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-10-30
Code: M
Action: Exercise or conversion
Quantity: 39042
Price: 17.92
Following holdings: 147,509
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 39042
transaction Price Per Share: 17.92
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 147509
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-10-30
Code: S
Action: Sale
Quantity: 41789
Price: 92.02
Following holdings: 105,720
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 41789
transaction Price Per Share: 92.02
id: F2
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 105720
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-10-30
Code: S
Action: Sale
Quantity: 16056
Price: 92.85
Following holdings: 89,664
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 16056
transaction Price Per Share: 92.85
id: F3
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 89664
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-10-30
Code: S
Action: Sale
Quantity: 6841
Price: 93.91
Following holdings: 82,823
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 6841
transaction Price Per Share: 93.91
id: F4
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 82823
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-10-30
Code: S
Action: Sale
Quantity: 4821
Price: 94.86
Following holdings: 78,002
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 4821
transaction Price Per Share: 94.86
id: F5
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 78002
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-10-30
Code: S
Action: Sale
Quantity: 4000
Price: 95.97
Following holdings: 74,002
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 4000
transaction Price Per Share: 95.97
id: F6
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 74002
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-10-30
Code: S
Action: Sale
Quantity: 1925
Price: 97.06
Following holdings: 72,077
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 1925
transaction Price Per Share: 97.06
id: F7
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 72077
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-10-30
Code: S
Action: Sale
Quantity: 2155
Price: 97.77
Following holdings: 69,922
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 2155
transaction Price Per Share: 97.77
id: F8
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 69922
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-11-02
Code: M
Action: Exercise or conversion
Quantity: 6455
Price: 30.93
Following holdings: 76,377
Reporting delay: 1 day
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 6455
transaction Price Per Share: 30.93
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 76377
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-11-02
Code: M
Action: Exercise or conversion
Quantity: 11958
Price: 17.92
Following holdings: 88,335
Reporting delay: 1 day
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 11958
transaction Price Per Share: 17.92
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 88335
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-11-02
Code: S
Action: Sale
Quantity: 899
Price: 92.37
Following holdings: 87,436
Reporting delay: 1 day
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 899
transaction Price Per Share: 92.37
id: F9
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 87436
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-11-02
Code: S
Action: Sale
Quantity: 16810
Price: 93.42
Following holdings: 70,626
Reporting delay: 1 day
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 16810
transaction Price Per Share: 93.42
id: F10
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 70626
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Owner: Paolini John F.
Date: 2026-11-02
Code: S
Action: Sale
Quantity: 704
Price: 94.09
Following holdings: 69,922
Reporting delay: 1 day
Filed terms and references: Filed terms
security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 704
transaction Price Per Share: 94.09
id: F11
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 69922
direct Or Indirect Ownership: D
nature Of Ownership:

Share Option (derivative)

Owner: Paolini John F.
Date: 2026-10-30
Code: M
Action: Exercise or conversion
Quantity: 38545
Price: 0
Following holdings: 6,455
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Share Option
conversion Or Exercise Price: 30.93
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 38545
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F12
expiration Date: 2028-09-19
underlying Security Title: Class A Ordinary Share
underlying Security Shares: 38545
shares Owned Following Transaction: 6455
direct Or Indirect Ownership: D
nature Of Ownership:

Share Option (derivative)

Owner: Paolini John F.
Date: 2026-10-30
Code: M
Action: Exercise or conversion
Quantity: 39042
Price: 0
Following holdings: 11,958
Reporting delay: 4 days
Filed terms and references: Filed terms
security Title: Share Option
conversion Or Exercise Price: 17.92
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 39042
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F12
expiration Date: 2029-03-03
underlying Security Title: Class A Ordinary Share
underlying Security Shares: 39042
shares Owned Following Transaction: 11958
direct Or Indirect Ownership: D
nature Of Ownership:

Share Option (derivative)

Owner: Paolini John F.
Date: 2026-11-02
Code: M
Action: Exercise or conversion
Quantity: 6455
Price: 0
Following holdings: 0
Reporting delay: 1 day
Filed terms and references: Filed terms
security Title: Share Option
conversion Or Exercise Price: 30.93
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 6455
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F12
expiration Date: 2028-09-19
underlying Security Title: Class A Ordinary Share
underlying Security Shares: 6455
shares Owned Following Transaction: 0
direct Or Indirect Ownership: D
nature Of Ownership:

Share Option (derivative)

Owner: Paolini John F.
Date: 2026-11-02
Code: M
Action: Exercise or conversion
Quantity: 11958
Price: 0
Following holdings: 0
Reporting delay: 1 day
Filed terms and references: Filed terms
security Title: Share Option
conversion Or Exercise Price: 17.92
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 11958
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F12
expiration Date: 2029-03-03
underlying Security Title: Class A Ordinary Share
underlying Security Shares: 11958
shares Owned Following Transaction: 0
direct Or Indirect Ownership: D
nature Of Ownership:

Purchases, sales, grants and option exercises are different transactions. The reported code identifies the action; it does not establish a motive.

Filing context

Quantities and prices are shown in the units filed. No trade value is inferred from their product.
Paolini John F.: CHIEF MEDICAL OFFICER.
The filing reports a Rule 10b5-1 trading plan.
F1: This transaction was effected pursuant to a Rule 10b5-1 plan executed by the reporting person on July 29, 2026.
F2: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $91.3575 and $92.355. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $92.36 and $93.35. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F4: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $93.42 and $94.385. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F5: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $94.42 and $95.24. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F6: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $95.485 and $96.465. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F7: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $96.565 and $97.415. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F8: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $97.60 and $98.30. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F9: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $92.00 and $92.805. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F10: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $93.02 and $94.00. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F11: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $94.025 and $94.135. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F12: The option is fully vested and exercisable.

Original sources

SEC ownership filing

Prepared automatically from public filing data. Report a correction.

Security

Owner

Date

Code

Action

Quantity

Price

Following holdings

Reporting delay

Filed terms and references

Class A Ordinary Share

Paolini John F.

2026-10-30

Exercise or conversion

38545

30.93

108,467

4 days

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 38545
transaction Price Per Share: 30.93
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 108467
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-10-30

Exercise or conversion

39042

17.92

147,509

4 days

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 39042
transaction Price Per Share: 17.92
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 147509
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-10-30

Sale

41789

92.02

105,720

4 days

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 41789
transaction Price Per Share: 92.02
id: F2
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 105720
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-10-30

Sale

16056

92.85

89,664

4 days

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 16056
transaction Price Per Share: 92.85
id: F3
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 89664
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-10-30

Sale

6841

93.91

82,823

4 days

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 6841
transaction Price Per Share: 93.91
id: F4
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 82823
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-10-30

Sale

4821

94.86

78,002

4 days

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 4821
transaction Price Per Share: 94.86
id: F5
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 78002
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-10-30

Sale

4000

95.97

74,002

4 days

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 4000
transaction Price Per Share: 95.97
id: F6
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 74002
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-10-30

Sale

1925

97.06

72,077

4 days

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 1925
transaction Price Per Share: 97.06
id: F7
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 72077
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-10-30

Sale

2155

97.77

69,922

4 days

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 2155
transaction Price Per Share: 97.77
id: F8
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 69922
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-11-02

Exercise or conversion

6455

30.93

76,377

1 day

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 6455
transaction Price Per Share: 30.93
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 76377
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-11-02

Exercise or conversion

11958

17.92

88,335

1 day

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 11958
transaction Price Per Share: 17.92
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 88335
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-11-02

Sale

899

92.37

87,436

1 day

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 899
transaction Price Per Share: 92.37
id: F9
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 87436
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-11-02

Sale

16810

93.42

70,626

1 day

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 16810
transaction Price Per Share: 93.42
id: F10
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 70626
direct Or Indirect Ownership: D
nature Of Ownership:

Class A Ordinary Share

Paolini John F.

2026-11-02

Sale

704

94.09

69,922

1 day

Filed terms

security Title: Class A Ordinary Share
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 704
transaction Price Per Share: 94.09
id: F11
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 69922
direct Or Indirect Ownership: D
nature Of Ownership:

Share Option (derivative)

Paolini John F.

2026-10-30

Exercise or conversion

38545

6,455

4 days

Filed terms

security Title: Share Option
conversion Or Exercise Price: 30.93
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 38545
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F12
expiration Date: 2028-09-19
underlying Security Title: Class A Ordinary Share
underlying Security Shares: 38545
shares Owned Following Transaction: 6455
direct Or Indirect Ownership: D
nature Of Ownership:

Share Option (derivative)

Paolini John F.

2026-10-30

Exercise or conversion

39042

11,958

4 days

Filed terms

security Title: Share Option
conversion Or Exercise Price: 17.92
transaction Date: 2026-10-30
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 39042
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F12
expiration Date: 2029-03-03
underlying Security Title: Class A Ordinary Share
underlying Security Shares: 39042
shares Owned Following Transaction: 11958
direct Or Indirect Ownership: D
nature Of Ownership:

Share Option (derivative)

Paolini John F.

2026-11-02

Exercise or conversion

6455

1 day

Filed terms

security Title: Share Option
conversion Or Exercise Price: 30.93
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 6455
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F12
expiration Date: 2028-09-19
underlying Security Title: Class A Ordinary Share
underlying Security Shares: 6455
shares Owned Following Transaction: 0
direct Or Indirect Ownership: D
nature Of Ownership:

Share Option (derivative)

Paolini John F.

2026-11-02

Exercise or conversion

11958

1 day

Filed terms

security Title: Share Option
conversion Or Exercise Price: 17.92
transaction Date: 2026-11-02
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 11958
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F12
expiration Date: 2029-03-03
underlying Security Title: Class A Ordinary Share
underlying Security Shares: 11958
shares Owned Following Transaction: 0
direct Or Indirect Ownership: D
nature Of Ownership:

Filing context

Quantities and prices are shown in the units filed. No trade value is inferred from their product.

Paolini John F.: CHIEF MEDICAL OFFICER.

The filing reports a Rule 10b5-1 trading plan.

F1: This transaction was effected pursuant to a Rule 10b5-1 plan executed by the reporting person on July 29, 2026.

F2: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $91.3575 and $92.355. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F3: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $92.36 and $93.35. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F4: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $93.42 and $94.385. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F5: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $94.42 and $95.24. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F6: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $95.485 and $96.465. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F7: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $96.565 and $97.415. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F8: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $97.60 and $98.30. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F9: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $92.00 and $92.805. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F10: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $93.02 and $94.00. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F11: This transaction was executed in multiple trades through a broker-dealer at prices ranging between $94.025 and $94.135. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

F12: The option is fully vested and exercisable.