SYRE: King-Jones Heidy discloses securities transactions

By AlphaYouPublished Oct 3, 2026Form 4

Stocks in this disclosure

Reported activity

King-Jones Heidy

Reporting filer

King-Jones Heidy reported Exercise or conversion in Spyre Therapeutics, Inc.: 28933 units of Common Stock, dated 2026-10-01. The full Form 4 contains 7 transaction entries.

Disclosed: Oct 3, 2026

Reported details

7 entries

All validated entries in this disclosure
Security	Owner	Date	Code	Action	Quantity	Price	Following holdings	Reporting delay	Filed terms and references
Common Stock	King-Jones Heidy	2026-10-01	M	Exercise or conversion	28933	14.50	31,778	2 days	Filed terms security Title: Common Stock transaction Date: 2026-10-01 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 28933 transaction Price Per Share: 14.50 transaction Acquired Disposed Code: A shares Owned Following Transaction: 31778 direct Or Indirect Ownership: D
Common Stock	King-Jones Heidy	2026-10-01	S	Sale	400	89.24	31,378	2 days	Filed terms security Title: Common Stock transaction Date: 2026-10-01 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 400 transaction Price Per Share: 89.24 id: F2 transaction Acquired Disposed Code: D shares Owned Following Transaction: 31378 direct Or Indirect Ownership: D
Common Stock	King-Jones Heidy	2026-10-01	S	Sale	16605	90.35	14,773	2 days	Filed terms security Title: Common Stock transaction Date: 2026-10-01 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 16605 transaction Price Per Share: 90.35 id: F3 transaction Acquired Disposed Code: D shares Owned Following Transaction: 14773 direct Or Indirect Ownership: D
Common Stock	King-Jones Heidy	2026-10-01	S	Sale	7228	91.35	7,545	2 days	Filed terms security Title: Common Stock transaction Date: 2026-10-01 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 7228 transaction Price Per Share: 91.35 id: F4 transaction Acquired Disposed Code: D shares Owned Following Transaction: 7545 direct Or Indirect Ownership: D
Common Stock	King-Jones Heidy	2026-10-01	S	Sale	2100	92.70	5,445	2 days	Filed terms security Title: Common Stock transaction Date: 2026-10-01 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 2100 transaction Price Per Share: 92.70 id: F5 transaction Acquired Disposed Code: D shares Owned Following Transaction: 5445 direct Or Indirect Ownership: D
Common Stock	King-Jones Heidy	2026-10-01	S	Sale	2600	93.46	2,845	2 days	Filed terms security Title: Common Stock transaction Date: 2026-10-01 transaction Form Type: 4 transaction Code: S equity Swap Involved: 0 id: F1 transaction Shares: 2600 transaction Price Per Share: 93.46 id: F6 transaction Acquired Disposed Code: D shares Owned Following Transaction: 2845 direct Or Indirect Ownership: D
Stock Option (Right to Buy) (derivative)	King-Jones Heidy	2026-10-01	M	Exercise or conversion	28933	0	482,478	2 days	Filed terms security Title: Stock Option (Right to Buy) conversion Or Exercise Price: 14.50 transaction Date: 2026-10-01 transaction Form Type: 4 transaction Code: M equity Swap Involved: 0 id: F1 transaction Shares: 28933 transaction Price Per Share: 0 transaction Acquired Disposed Code: D id: F7 expiration Date: 2033-09-01 underlying Security Title: Common Stock underlying Security Shares: 28933 shares Owned Following Transaction: 482478 direct Or Indirect Ownership: D

Common Stock

Owner: King-Jones Heidy
Date: 2026-10-01
Code: M
Action: Exercise or conversion
Quantity: 28933
Price: 14.50
Following holdings: 31,778
Reporting delay: 2 days
Filed terms and references: Filed terms
security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 28933
transaction Price Per Share: 14.50
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 31778
direct Or Indirect Ownership: D

Common Stock

Owner: King-Jones Heidy
Date: 2026-10-01
Code: S
Action: Sale
Quantity: 400
Price: 89.24
Following holdings: 31,378
Reporting delay: 2 days
Filed terms and references: Filed terms
security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 400
transaction Price Per Share: 89.24
id: F2
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 31378
direct Or Indirect Ownership: D

Common Stock

Owner: King-Jones Heidy
Date: 2026-10-01
Code: S
Action: Sale
Quantity: 16605
Price: 90.35
Following holdings: 14,773
Reporting delay: 2 days
Filed terms and references: Filed terms
security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 16605
transaction Price Per Share: 90.35
id: F3
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 14773
direct Or Indirect Ownership: D

Common Stock

Owner: King-Jones Heidy
Date: 2026-10-01
Code: S
Action: Sale
Quantity: 7228
Price: 91.35
Following holdings: 7,545
Reporting delay: 2 days
Filed terms and references: Filed terms
security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 7228
transaction Price Per Share: 91.35
id: F4
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 7545
direct Or Indirect Ownership: D

Common Stock

Owner: King-Jones Heidy
Date: 2026-10-01
Code: S
Action: Sale
Quantity: 2100
Price: 92.70
Following holdings: 5,445
Reporting delay: 2 days
Filed terms and references: Filed terms
security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 2100
transaction Price Per Share: 92.70
id: F5
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 5445
direct Or Indirect Ownership: D

Common Stock

Owner: King-Jones Heidy
Date: 2026-10-01
Code: S
Action: Sale
Quantity: 2600
Price: 93.46
Following holdings: 2,845
Reporting delay: 2 days
Filed terms and references: Filed terms
security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 2600
transaction Price Per Share: 93.46
id: F6
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 2845
direct Or Indirect Ownership: D

Stock Option (Right to Buy) (derivative)

Owner: King-Jones Heidy
Date: 2026-10-01
Code: M
Action: Exercise or conversion
Quantity: 28933
Price: 0
Following holdings: 482,478
Reporting delay: 2 days
Filed terms and references: Filed terms
security Title: Stock Option (Right to Buy)
conversion Or Exercise Price: 14.50
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 28933
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F7
expiration Date: 2033-09-01
underlying Security Title: Common Stock
underlying Security Shares: 28933
shares Owned Following Transaction: 482478
direct Or Indirect Ownership: D

Purchases, sales, grants and option exercises are different transactions. The reported code identifies the action; it does not establish a motive.

Filing context

Quantities and prices are shown in the units filed. No trade value is inferred from their product.
King-Jones Heidy: See Remarks.
The filing reports a Rule 10b5-1 trading plan.
F1: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on April 16, 2026.
F2: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $88.63 to $89.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.
F3: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $89.96 to $90.95, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
F4: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $91.10 to $92.09, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
F5: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $92.12 to $93.09, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
F6: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $93.17 to $93.75, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.
F7: This option represents the right to purchase 539,810 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's continued employment with the Issuer.

Original sources

SEC ownership filing

Prepared automatically from public filing data. Report a correction.

Security

Owner

Date

Code

Action

Quantity

Price

Following holdings

Reporting delay

Filed terms and references

Common Stock

King-Jones Heidy

2026-10-01

Exercise or conversion

28933

14.50

31,778

2 days

Filed terms

security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 28933
transaction Price Per Share: 14.50
transaction Acquired Disposed Code: A
shares Owned Following Transaction: 31778
direct Or Indirect Ownership: D

Common Stock

King-Jones Heidy

2026-10-01

Sale

400

89.24

31,378

2 days

Filed terms

security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 400
transaction Price Per Share: 89.24
id: F2
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 31378
direct Or Indirect Ownership: D

Common Stock

King-Jones Heidy

2026-10-01

Sale

16605

90.35

14,773

2 days

Filed terms

security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 16605
transaction Price Per Share: 90.35
id: F3
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 14773
direct Or Indirect Ownership: D

Common Stock

King-Jones Heidy

2026-10-01

Sale

7228

91.35

7,545

2 days

Filed terms

security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 7228
transaction Price Per Share: 91.35
id: F4
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 7545
direct Or Indirect Ownership: D

Common Stock

King-Jones Heidy

2026-10-01

Sale

2100

92.70

5,445

2 days

Filed terms

security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 2100
transaction Price Per Share: 92.70
id: F5
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 5445
direct Or Indirect Ownership: D

Common Stock

King-Jones Heidy

2026-10-01

Sale

2600

93.46

2,845

2 days

Filed terms

security Title: Common Stock
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: S
equity Swap Involved: 0
id: F1
transaction Shares: 2600
transaction Price Per Share: 93.46
id: F6
transaction Acquired Disposed Code: D
shares Owned Following Transaction: 2845
direct Or Indirect Ownership: D

Stock Option (Right to Buy) (derivative)

King-Jones Heidy

2026-10-01

Exercise or conversion

28933

482,478

2 days

Filed terms

security Title: Stock Option (Right to Buy)
conversion Or Exercise Price: 14.50
transaction Date: 2026-10-01
transaction Form Type: 4
transaction Code: M
equity Swap Involved: 0
id: F1
transaction Shares: 28933
transaction Price Per Share: 0
transaction Acquired Disposed Code: D
id: F7
expiration Date: 2033-09-01
underlying Security Title: Common Stock
underlying Security Shares: 28933
shares Owned Following Transaction: 482478
direct Or Indirect Ownership: D

Filing context

Quantities and prices are shown in the units filed. No trade value is inferred from their product.

King-Jones Heidy: See Remarks.

The filing reports a Rule 10b5-1 trading plan.

F1: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on April 16, 2026.

F2: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $88.63 to $89.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

F3: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $89.96 to $90.95, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F4: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $91.10 to $92.09, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F5: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $92.12 to $93.09, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F6: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $93.17 to $93.75, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F7: This option represents the right to purchase 539,810 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's continued employment with the Issuer.