Price action
Daily adjusted bars
Snapshot
Key stats
- Market cap
- $39.47B
- P/E ratio
- 74.09
- Forward P/E
- 31.65
- Beta
- 0.30
- 52W range
- $284.28 - $495.55
- Dividend yield
- --
- Volume
- 4.29M
- Sector
- HEALTHCARE
Analyst
Consensus price target
Current
$295.06
Target
$445.81
AlphaYou verdict
Insider Cluster
Smart-money signal on ALNY this 14d.
- Smart money5.0/40
- Fundamentals6.0/35
- Technicals1.0/15
- Macro2.0/10
Receipts
Recent signals for this ticker
- LONGMay 15Insider Cluster
Smart-money signal on ALNY this 14d.
Public Recommendation·Checkpoints pending
Smart money
Insider, fund, and political flow
filing 13f fund flow
TWO SIGMA INVESTMENTS, LP increased position ($659.3M) (+223%)
filing nport p fund flow
American Funds Insurance Series holds $455.3M (NPORT-P 2025-12-31)
filing nport p fund flow
Janus Investment Fund (legacy active) holds $18.2M (NPORT-P 2026-09-30)
filing 13f fund flow
Citadel Advisors LLC holds $15.3M (13F 2025-12-31)
filing nport p fund flow
Janus Detroit Street Trust (active ETFs) holds $313K (NPORT-P 2026-10-31)
filing 13f fund flow
FMR LLC (Fidelity) holds $6.3B (13F 2025-12-31)
Top trader activity
PendingCopy-trading signal layer from real US-equity operators. Wires in once the CopyTrading feed is mapped to US-stock tickers.
BTC Astro risk regime
PendingCross-asset risk timing overlay. Used as context only, never a primary stock source.
Reputation
Sources and actors behind this ticker
Source families
- SEC EDGAR 13F
Source family
D7
92
+1.17%
60.9% hit
D15
pending
D30
pending
Actors and filers
- TWO SIGMA INVESTMENTS, LP
FORM 13F FILER
D7
77
+1.55%
64.9% hit
D15
pending
D30
pending
Checkpoint ledger
Public recommendation outcomes
No public recommendation checkpoints have landed for this ticker yet.
D7 appears first, then D15 and D30 as the call matures.
Each row is a public recommendation. Alpha columns compare the frozen issued price with SPY, QQQ, and sector ETF checkpoints when available.
Raw source coverage
Primary-source receipt chain
- raw linked
SEC EDGAR 13F
FILING 13F FUND FLOW · May 15· source
Fundamentals
Valuation, quality, growth
Valuation
- P/E74.09
- Forward P/E31.65
- P/S9.21
- P/B36.70
Quality
- Profit margin12.6%
- Operating margin23.0%
- ROE90.4%
- ROA10.1%
Growth
- Revenue YoY--
- Earnings YoY--
- Beta0.30
- Dividend yield--
Technicals
Trend, momentum, levels
Trailing returns
- 5d+1.08%
- 20d-0.16%
- 60d-0.68%
Trend vs SMAs
- vs SMA50+0.62%
- vs SMA200-0.23%
52w range position
Computed from AV daily adjusted bars. No options-flow, IV, or order-book signals on this page yet.
Macro
Sector + regime context
- +17.3
macro regime shift
VIX 17.3 (mild) as of 2026-05-14
- +0.5
macro regime shift
10y-2y spread 47bps (flattish) as of 2026-05-14
- +102.5
macro regime shift
Industrial Production 102.5 (mild expansion) as of 2026-04-01
- +1.0
macro regime shift
Initial claims 211,000 vs 26w mean (ratio 0.99, neutral)
- +4.0
macro regime shift
CPI YoY 3.95% (hot vs Fed target)
Earnings
EPS beat / miss history
Debate
Key issues
Bullish view
- TWO SIGMA INVESTMENTS, LP increased position ($659.3M) (+223%)
- American Funds Insurance Series holds $455.3M (NPORT-P 2025-12-31)
- Janus Investment Fund (legacy active) holds $18.2M (NPORT-P 2026-09-30)
- Citadel Advisors LLC holds $15.3M (13F 2025-12-31)
Bearish view
No receipts on this side yet.
Arguments are pulled from contributing receipts (Form 4 / 13F / fundamentals / macro) for this ticker. Each side carries the count of receipts behind it, not an analyst headline count.
Track record
Recommendation receipts
vs SPY
S&P 500
Median alpha
+2.76%
Mean alpha
+2.76%
Hit rate
100.0%
Mean return
+3.65%
vs QQQ
Nasdaq-100
Median alpha
+2.44%
Mean alpha
+2.44%
Hit rate
100.0%
Mean return
+3.65%
D7 recommendation-counted alpha. Each receipt aggregates same-day same-direction signals into one row to avoid double-counting.